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Newcastle Science Festival Review


The Big Biotech Debate

Bryan Vernon reports on a debate held as part of the first Newcastle Science Festival,
International Centre for Life, 16 April 2003.

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Speakers: Francis Fukuyama, Professor of International Political Economy at John Hopkins University, member of George Bush's recently formed Bioethics Council and author of Our Posthuman Future and the international bestseller The End of History and the Last Man and Gregory Stock, Director of Medical Technology and Society at UCLA, former bioethics advisor to Bill Clinton and author of Redesigning Humans

Alistair Balls, CEO of the International Centre for Life, introduced the debate, saying that both speakers agreed that we were on the cusp of biological change with profound consequences, and that nothing should be done until it could be shown to be safe.

Professor Fukuyama put the case for caution. His background was in political science rather than the life sciences. The twentieth century had revolved around a number of attempts at grand experiments in social justice, all of which had foundered because of human nature. He saw many promising areas of development in the life sciences with clear therapeutic gains, but identified three areas for caution.

  1. Neuropharmacology. There had been a revolution in psychiatry. We had moved from genetic determinism at the beginning of the twentieth century through the social constructionism of the mid-20th Century to a restoration of the importance of nature. The biological basis for the functions of the brain was now better understood. This had led to the development of drugs like Prozac and Ritalin, both of which are inherently political drugs. Prozac provides a medical shortcut to the political manipulation of human personality. It is a drug for creating self- esteem. ADHD (Attention deficit hyperactivity disorder) represents the medicalisation of normally distributed human behaviour. Ritalin is an agent of social control of children.

  2. Life extension. While this is individually desirable, the social benefits are questionable. Already Italy faces a future where the median age of the population will be 60. Generational turnover helps the process of social change.

  3. Germline engineering - if we reach this point. The concept of human rights, deeply embedded in the US Constitution, is dependent on human nature. A technology that can alter human nature could alter human rights. The Constitution describes certain inalienable rights, but there is a question as to who qualifies for these. In 1776 blacks and women were excluded. Professor Fukuyama was content that these technologies be used to target disease, but troubled about their use for non-therapeutic purposes like enhancement. Proponents of individual choice in this area fail to take account of market failures. At the moment 117- 122 boys are born in China and South Korea per 100 girls.

Large social changes often have unanticipated consequences, just as building a large dam affects those downstream. Regulating this process is not outlandish. Scientific research is already regulated and researchers are familiar and comfortable with Institutional Review Boards (US) and Local Research Ethics Committees (UK).

In his response, Gregory Stock said that he found much of what had been said sounded reasonable, but that it would be impossible to regulate for the future and was indeed undesirable to do so. He said that it was inevitable that the scientific exploration envisaged would occur. He deplored the proposed US legislation to outlaw stem cell work which was directed at alleviating the suffering of real people with real conditions.

Stock resisted the description of those who would regulate as realists. The true realists recognised the unparalleled breakthroughs which the silicon revolution and the genomics revolution would inevitably bring. The way we have children, treat illness and use technologies to alter behaviour and lifespan would change in an unstoppable movement. This cannot be stopped, just as wealthy Germans go to Brussels or London for treatment involving their embryos which is outlawed in Germany.

He was scathing about the war on drugs and wondered why anyone would want to regulate a drug that created happiness with no side effects. People are already asking to make choices about the predispositions and temperament of their children. Why stop them? Sex selection has not created gender imbalance in the West. Who is a victim if a couple wish to avoid having a girl or a boy? How can you police the boundary between needs and desires?

Such a future is inevitable as a spin-off from mainstream medical technology.

In response, Professor Fukuyama said that he was not afraid that the technologies would not work. If this were to be the case, some would be relieved. He saw that humanity faced irresistible seductive choices as a result of which we would lose our souls. We are not worried about our ability to handle these choices, typically, but are anxious about the person next door.

Gregory Stock said that people concerned about the technologies need not have recourse to them. He pointed out that our great grandparents might not be happy with the state of things today, but that we were, and should not shackle our great grandchildren. He said that we need to grow up and that we should embrace the opportunity to decide when we wish to die. The inherent problem with planning is that we cannot fathom the values of future humans. The next frontier is not space, but ourselves.

He did not answer Professor Fukuyama's question when challenged as to whether he believed the Human Fertilisation and Embryology Authority should be disbanded.

Bryan Vernon

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Bryan Vernon is Lecturer in Health Care Ethics in the School of Population and Health Sciences (SPAHS) in Newcastle's Medical School. He has a degree in Law and is an Anglican priest. He chaired the Newcastle Mental Health NHS Trust from 1990-4 and now chairs Independent Review Panels in the NHS Complaints Process.


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Redesigning Humans Our Posthuman Future The End of History


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